DLG5 Antibody

Size

100ul

Clone Number

Aliases

Discs large homolog 5 (Drosophila) antibody; Discs large homolog 5 antibody; Discs large protein LP DLG antibody; Discs large protein P dlg antibody; Discs large protein P-dlg antibody; Disks large homolog 5 antibody; DLG 5 antibody; DLG5 antibody; DLG5_HUMAN antibody; KIAA0583 antibody; Large type of P DLG antibody; LP DLG antibody; P DLG5 antibody; PDLG antibody; Placenta and prostate DLG antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q8TDM6

Immunogen

Recombinant Human Disks large homolog 5 protein (1580-1704AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IF; Recommended dilution: IF:1:50-1:200

Background

Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360). Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

DLG5

Research Areas

Signal transduction