DICER1 Antibody, HRP conjugated

Size

100ul

Clone Number

Aliases

DCR antibody; DCR1 antibody; Dicer 1 ribonuclease III antibody; Dicer 1 ribonuclease type III antibody; Dicer antibody; DICER_HUMAN antibody; DICER1 antibody; Double-strand-specific ribonuclease antibody; Endoribonuclease Dicer antibody; Helicase MOI antibody; Helicase with RNase motif antibody; HERNA antibody; KIAA0928 antibody; MNG1 antibody; RMSE2 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9UPY3

Immunogen

Recombinant Human Endoribonuclease Dicer protein (1721-1922AA )

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA

Background

Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3\' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

HRP

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

DICER1

Research Areas

Epigenetics and Nuclear Signaling