DIABLO Antibody

Size

100ug

Clone Number

Aliases

0610041G12Rik antibody; DBLOH_HUMAN antibody; DBOH antibody; DFNA64 antibody; diablo antibody; Diablo homolog (Drosophila) antibody; Diablo homolog antibody; Diablo homolog mitochondrial antibody; Diablo IAP binding mitochondrial protein antibody; Diablo like protein antibody; DIABLO S antibody; Direct IAP binding protein with low pI antibody; Direct IAP-binding protein with low pI antibody; FLJ10537 antibody; FLJ25049 antibody; mitochondrial antibody; Mitochondrial Smac protein antibody; Second mitochondria derived activator of caspase antibody; Second mitochondria-derived activator of caspase antibody; second mitochondrial activator of caspases antibody; SMAC 3 antibody; Smac antibody; Smac protein antibody; SMAC3 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9NR28

Immunogen

Recombinant Human Diablo homolog, mitochondrial protein (168-236AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

Background

Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis-inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

DIABLO

Research Areas

Cancer; Cell biology; Metabolism