DHX36 Antibody, HRP conjugated

Size

100ug

Clone Number

Aliases

DDX36 antibody; DEAH box protein 36 antibody; Dhx36 antibody; DHX36_HUMAN antibody; EC 3.6.1.- antibody; KIAA1488 antibody; MLE like protein 1 antibody; MLE-like protein 1 antibody; MLEL1 antibody; Probable ATP dependent RNA helicase DHX36 antibody; Probable ATP-dependent RNA helicase DHX36 antibody; RHAU antibody; RNA helicase associated with AU rich element ARE antibody; RNA helicase associated with AU-rich element ARE antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9H2U1

Immunogen

Recombinant Human ATP-dependent RNA helicase DHX36 protein (68-181AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA

Background

Proposed to have a global role in regulating mRNA expression including transcriptional regulation and mRNA stability. Binds with high affinity to and resolves tetramolecular RNA and DNA quadruplex structures. Unwinds intramolecular quadruplexes derived from the ZIC1 and the MYC promoters. Binds to quadruplex structures in the promoters of YY1 and ALPL genes and regulates their expression. Binds to telomerase RNA template component (TERC) 5\'-end (nucleotides 1-43) and unwinds an internal quadruplex formation in TERC 5\'-end to promote P1 helix formation; the P1 helix acts as a template boundary ensuring accurate reverse transcription and is disrupted by quadruplex formation. May be involved in regulation of telomere length. Plays a role in degradation and deadenylation of mRNAs containing in their 3\'-UTR the consensus ARE sequence element. May function in sex development and spermatogenesis. May play a role in ossification.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

HRP

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

DHX36

Research Areas

Epigenetics and Nuclear Signaling