Dexras2 Polyclonal Antibody

Ab type

Primary antibody

Background

RASD2 belongs to the Ras superfamily of small GTPases and is enriched in the striatum. The RASD family member 2 functions as an E3 ligase for attachment of small ubiquitin-like modifier (SUMO). This protein also binds to mutant huntingtin (mHtt), the protein mutated in Huntington disease (HD). Sumoylation of mHTT by this protein may cause degeneration of the striatum. The protein functions as an activator of mechanistic target of rapamycin 1 (mTOR1), which in turn plays a role in myelination, axon growth and regeneration. Reduced levels of mRNA expressed by this gene were found in HD patients.

Reactivity

Human;Mouse;Rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

The antiserum was produced against synthesized peptide derived from human RASD2. AA range:217-266

Storage Stability

-20°C for one year

Concentration

1 mg/ml

MolecularWeight_Da

30366

synonyms

RASD2; TEM2; GTP-binding protein Rhes; Ras homolog enriched in striatum; Tumor endothelial marker 2