DEAF1 Antibody

Size

100ug

Clone Number

Aliases

Deaf1 antibody; DEAF1 transcription factor antibody; DEAF1_HUMAN antibody; Deformed epidermal autoregulatory factor 1 homolog antibody; Nuclear DEA1 related transcriptional regulator antibody; Nuclear DEAF-1-related transcriptional regulator antibody; NUDR antibody; SPN antibody; Suppressin antibody; Zinc finger MYND domain containing protein 5 antibody; Zinc finger MYND domain-containing protein 5 antibody; ZMYND5 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

O75398

Immunogen

Recombinant Human Deformed epidermal autoregulatory factor 1 homolog protein (73-200AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, WB; Recommended dilution: WB:1:500-1:5000

Background

Transcription factor that binds to sequence with multiple copies of 5\\\'-TTC[CG]G-3\\\' present in its own promoter and that of the HNRPA2B1 gene. Down-regulates transcription of these genes. Binds to the retinoic acid response element (RARE) 5\\\'-AGGGTTCACCGAAAGTTCA-3\\\'. Activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction. When secreted, behaves as an inhibitor of cell proliferation, by arresting cells in the G0 or G1 phase. Required for neural tube closure and skeletal patterning. Regulates epithelial cell proliferation and side-branching in the mammary gland. Controls the expression of peripheral tissue antigens in pancreatic lymph nodes. Isoform 1 displays greater transcriptional activity than isoform 4. Isoform 4 may inhibit transcriptional activity of isoform 1 by interacting with isoform 1 and retaining it in the cytoplasm. Transcriptional activator of EIF4G3.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

DEAF1

Research Areas

Epigenetics and Nuclear Signaling; Cell biology