DDX20 Antibody

Size

100ul

Clone Number

Aliases

Component of gems 3 antibody; DDX 20 antibody; ddx20 antibody; DDX20_HUMAN antibody; DEAD (Asp Glu Ala Asp) box polypeptide 20 antibody; DEAD box protein 20 antibody; DEAD box protein DP 103 antibody; DEAD box protein DP103 antibody; DEAD/H (Asp Glu Ala Asp/His) box polypeptide 20 103kD antibody; DEAD/H (Asp Glu Ala Asp/His) box polypeptide 20 antibody; DEAD/H BOX 20 antibody; DKFZP434H052 antibody; DP 103 antibody; DP103 antibody; Gemin-3 antibody; Gemin3 antibody; Probable ATP dependent RNA helicase DDX20 antibody; Probable ATP-dependent RNA helicase ddx20 antibody; SMN interacting protein antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9UHI6

Immunogen

Recombinant Human Probable ATP-dependent RNA helicase DDX20 protein (25-280AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200

Background

The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs).

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

DDX20

Research Areas

Epigenetics and Nuclear Signaling; Neuroscience; Signal transduction