DDX11 Antibody

Size

100ul

Clone Number

Aliases

CHL1 antibody; CHL1 related helicase gene 1 antibody; CHL1-like helicase homolog antibody; CHL1-related protein 1 antibody; CHLR1 antibody; Ddx11 antibody; DDX11_HUMAN antibody; DEAD/H (Asp Glu Ala Asp/His) box polypeptide 11 antibody; DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 antibody; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 (CHL1-like helicase homolog; S. cerevisiae) antibody; DEAD/H box antibody; DEAD/H box protein 11 antibody; hCHLR1 antibody; Keratinocyte growth factor regulated gene 2 protein antibody; Keratinocyte growth factor-regulated gene 2 protein antibody; KRG 2 antibody; KRG-2 antibody; KRG2 antibody; MGC133249 antibody; MGC9335 antibody; OTTHUMP00000238778 antibody; OTTHUMP00000238780 antibody; OTTHUMP00000238784 antibody; OTTHUMP00000238785 antibody; Probable ATP dependent RNA helicase DDX11 antibody; Probable ATP-dependent RNA helicase DDX11 antibody; WABS antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q96FC9

Immunogen

Recombinant Human ATP-dependent DNA helicase DDX11 protein (1-220AA)

Raised in

Rabbit

Species Reactivity

Human, Mouse

Tested Applications

ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200

Background

DNA helicase involved in cellular proliferation. Possesses DNA-dependent ATPase and helicase activities. This helicase translocates on single-stranded DNA in the 5\\\' to 3\\\' direction in the presence of ATP and, to a lesser extent, dATP. Its unwinding activity requires a 5\\\'-single-stranded region for helicase loading, since flush-ended duplex structures do not support unwinding. The helicase activity is capable of displacing duplex regions up to 100 bp, which can be extended to 500 bp by RPA or the cohesion establishment factor, the Ctf18-RFC (replication factor C) complex activities. Stimulates the flap endonuclease activity of FEN1. Required for normal sister chromatid cohesion. Required for recruitment of bovine papillomavirus type 1 regulatory protein E2 to mitotic chrmosomes and for viral genome maintenance. Required for maintaining the chromosome segregation and is essential for embryonic development and the prevention of aneuploidy. May function during either S, G2, or M phase of the cell cycle. Binds to both single- and double-stranded DNA.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

DDX11

Research Areas

Epigenetics and Nuclear Signaling; Cell biology