DDR2 Antibody

Size

100ug

Clone Number

Aliases

CD167 antigen-like family member B antibody; CD167b antibody; CD167b antigen antibody; Cell migration inducing protein 20 antibody; DDR 2 antibody; DDR2 antibody; DDR2_HUMAN antibody; Discoidin domain containing receptor 2 antibody; Discoidin domain receptor 2 antibody; Discoidin domain receptor family member 2 antibody; discoidin domain receptor tyrosine kinase 2 antibody; Discoidin domain-containing receptor 2 antibody; discoidin domain-containing receptor tyrosine kinase 2 antibody; Hydroxyaryl protein kinase antibody; MIG20a antibody; Migration inducing gene 16 protein antibody; Neurotrophic tyrosine kinase antibody; Neurotrophic tyrosine kinase receptor related 3 antibody; NTRKR 3 antibody; NTRKR3 antibody; Receptor protein tyrosine kinase TKT antibody; Receptor protein-tyrosine kinase TKT antibody; Receptor related 3 antibody; receptor-related 3 antibody; TKT antibody; TYRO 10 antibody; TYRO10 antibody; Tyrosine kinase receptor related to neurotrophic TRK antibody; Tyrosine protein kinase TYRO 10 antibody; Tyrosine protein kinase TYRO10 antibody; Tyrosine-protein kinase TYRO10 antibody; Tyrosylprotein kinase antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q16832

Immunogen

Recombinant Human Discoidin domain-containing receptor 2 protein (447-540AA)

Raised in

Rabbit

Species Reactivity

Human, Mouse

Tested Applications

ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200

Background

Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

DDR2

Research Areas

Neuroscience; Cardiovascular