DCLRE1C Antibody

Size

100ul

Clone Number

Aliases

A SCID antibody; A SCID protein antibody; Artemis protein antibody; ASCID antibody; DCLRE1C antibody; DCLRE1C DNA cross link repair 1C antibody; DCLRE1C protein antibody; DCLREC1C antibody; DCR1C_HUMAN antibody; DNA cross link repair 1C antibody; DNA cross link repair 1C protein antibody; DNA cross-link repair 1C protein antibody; FLJ11360 antibody; FLJ36438 antibody; hSNM1C antibody; OTTHUMP00000045150 antibody; Protein A-SCID antibody; Protein ARTEMIS antibody; PSO2 homolog antibody; RS SCID antibody; SCIDA antibody; Severe combined immunodeficiency type a antibody; SNM1 homolog C antibody; SNM1 like protein antibody; SNM1-like protein antibody; SNM1C antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q96SD1

Immunogen

Recombinant Human Protein artemis protein (1-300AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA

Background

Required for V(D)J recombination, the process by which exons encoding the antigen-binding domains of immunoglobulins and T-cell receptor proteins are assembled from individual V, (D), and J gene segments. V(D)J recombination is initiated by the lymphoid specific RAG endonuclease complex, which generates site specific DNA double strand breaks (DSBs). These DSBs present two types of DNA end structures: hairpin sealed coding ends and phosphorylated blunt signal ends. These ends are independently repaired by the non homologous end joining (NHEJ) pathway to form coding and signal joints respectively. This protein exhibits single-strand specific 5\\\'-3\\\' exonuclease activity in isolation and acquires endonucleolytic activity on 5\\\' and 3\\\' hairpins and overhangs when in a complex with PRKDC. The latter activity is required specifically for the resolution of closed hairpins prior to the formation of the coding joint. May also be required for the repair of complex DSBs induced by ionizing radiation, which require substantial end-processing prior to religation by NHEJ.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

DCLRE1C

Research Areas

Epigenetics and Nuclear Signaling