CYP4V2 Antibody

Size

100ul

Clone Number

Aliases

BCD antibody; CP4V2_HUMAN antibody; CYP4AH1 antibody; CYP4V 2 antibody; CYP4V2 antibody; Cytochrome P450 4V2 antibody; Cytochrome P450; family 4; subfamily V; polypeptide 2 antibody; Retina CYP4V2 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q6ZWL3

Immunogen

Recombinant Human Cytochrome P450 4V2 protein (246-525AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

Omega-hydroxylase that oxidizes medium-chain saturated fatty acids and polyunsaturated omega-3 fatty acids, and which plays a role in fatty acid and steroid metabolism in the eye (PubMed:19661213, PubMed:22772592). Catalyzes the omega-hydroxylation of medium-chain saturated fatty acids such as laurate, myristate and palmitate in an NADPH-dependent pathway. The substrate specificity is higher for myristate > laurate > palmitate (C14>C16>C12) (PubMed:19661213). Acts as a polyunsaturated omega-3 fatty acids hydroxylase by mediating oxidation of docosahexaenoate (DHA) to 22-hydroxydocosahexaenoate (PubMed:22772592). Also produces some 21-hydroxydocosahexaenoate. Also converts eicosapentaenoate (EPA) to 20-hydroxyeicosapentaenoate (20-OH-EPA) (PubMed:22772592).

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

CYP4V2

Research Areas

Cancer; Cardiovascular; Metabolism