CYP3A4 Antibody, FITC conjugated

Size

100ug

Clone Number

Aliases

1,8-cineole 2-exo-monooxygenase antibody; Albendazole monooxygenase antibody; Albendazole sulfoxidase antibody; CP33 antibody; CP34 antibody; CP3A4_HUMAN antibody; CYP3 antibody; CYP3A antibody; CYP3A3 antibody; CYP3A4 antibody; CYPIIIA3 antibody; CYPIIIA4 antibody; Cytochrome P450 3A3 antibody; Cytochrome P450 3A4 antibody; Cytochrome P450 family 3 subfamily A polypeptide 4 antibody; Cytochrome P450 HLp antibody; Cytochrome P450 NF-25 antibody; Cytochrome P450 subfamily IIIA polypeptide 4 antibody; cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3 antibody; cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4 antibody; Cytochrome P450-PCN1 antibody; Glucocorticoid inducible P450 antibody; HLP antibody; MGC126680 antibody; NF 25 antibody; NF25 antibody; Nifedipine oxidase antibody; P450 III steroid inducible antibody; P450 PCN1 antibody; P450, family III antibody; P450C3 antibody; P450PCN1 antibody; Quinine 3 monooxygenase antibody; Quinine 3-monooxygenase antibody; Taurochenodeoxycholate 6 alpha hydroxylase antibody; Taurochenodeoxycholate 6-alpha-hydroxylase antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

P08684

Immunogen

Recombinant Human Cytochrome P450 3A4 protein (259-441AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

Background

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1\'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide (PubMed:11159812). Catalyzes 4-beta-hydroxylation of cholesterol. May catalyze 25-hydroxylation of cholesterol in vitro (PubMed:21576599).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

FITC

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

CYP3A4

Research Areas

Cancer; Cardiovascular; Metabolism; Signal transduction