CYLD Antibody

Size

100ug

Clone Number

Aliases

BRSS antibody; CDMT antibody; Cyld antibody; CYLD gene antibody; CYLD_HUMAN antibody; CYLD1 antibody; CYLDI antibody; cylindromatosis (turban tumor syndrome) antibody; cylindromatosis 1 antibody; Deubiquitinating enzyme CYLD antibody; EAC antibody; HSPC057 antibody; KIAA0849 antibody; MFT antibody; MFT1 antibody; Probable ubiquitin carboxyl terminal hydrolase CYLD antibody; SBS antibody; TEM antibody; turban tumor syndrome antibody; Ubiquitin carboxyl-terminal hydrolase CYLD antibody; ubiquitin specific peptidase like 2 antibody; ubiquitin thioesterase CYLD antibody; Ubiquitin thiolesterase CYLD antibody; Ubiquitin-specific processing protease CYLD antibody; Ubiquitin-specific-processing protease CYLD antibody; USPL2 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9NQC7

Immunogen

Recombinant Human Ubiquitin carboxyl-terminal hydrolase CYLD protein (269-435AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

Background

Deubiquitinase that specifically cleaves \'Lys-63\'-linked polyubiquitin chains. Has endodeubiquitinase activity. Plays an important role in the regulation of pathways leading to NF-kappa-B activation (PubMed:12917689, PubMed:12917691). Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation (PubMed:12917690). Negative regulator of Wnt signaling (PubMed:20227366). Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules (PubMed:19893491). Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis (PubMed:18222923, PubMed:20194890). Required for normal cell cycle progress and normal cytokinesis (PubMed:17495026, PubMed:19893491). Inhibits nuclear translocation of NF-kappa-B. Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation (PubMed:18636086). Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells. Negatively regulates TNFRSF11A signaling and osteoclastogenesis (By similarity). Involved in the regulation of ciliogenesis, allowing ciliary basal bodies to migrate and dock to the plasma membrane; this process does not depend on NF-kappa-B activation (By similarity). Also able to remove linear (\'Met-1\'-linked) polyubiquitin chains to regulate innate immunity: recruited to the LUBAC complex and, together with OTULIN, restricts linear polyubiquitin formation on RIPK2 in response to NOD2 stimulation (PubMed:26670046, PubMed:26997266).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

CYLD

Research Areas

Others