Cyclin D1 Polyclonal Antibody

Ab type

Primary antibody

Background

Cyclin D1 encoded by CCND1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. Cyclin D1 has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of CCND1, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.

Reactivity

Rat;Mouse

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

Recombinant Protein of Cyclin D1

Storage Stability

-20°C for one year

Concentration

1 mg/ml

MolecularWeight_Da

33729

synonyms

G1/S-specific cyclin-D1 (B-cell lymphoma 1 protein) (BCL-1) (BCL-1 oncogene) (PRAD1 oncogene)