CTH Antibody

Size

100ug

Clone Number

Aliases

CGL_HUMAN antibody; CTH antibody; cystathionase (cystathionine gamma-lyase) antibody; Cystathionine gamma lyase antibody; Cystathionine gamma-lyase antibody; Cysteine desulfhydrase antibody; Gamma cystathionase antibody; Gamma-cystathionase antibody; Homoserine deaminase antibody; Homoserine dehydratase antibody; MGC9471 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

P32929

Immunogen

Recombinant Human Cystathionine gamma-lyase protein (1-70AA)

Raised in

Rabbit

Species Reactivity

Human, Mouse, Rat

Tested Applications

ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200

Background

Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target proteins: sulfhydration consists of converting -SH groups into -SSH on specific cysteine residues of target proteins such as GAPDH, PTPN1 and NF-kappa-B subunit RELA, thereby regulating their function.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

CTH

Research Areas

Cancer; Metabolism; Signal transduction