CSPG4 Antibody

Size

100ul

Clone Number

Aliases

4732461B14Rik antibody; AN2 antibody; AN2 proteoglycan antibody; Chondroitin sulfate proteoglycan 4 (melanoma-associated) antibody; Chondroitin sulfate proteoglycan 4 antibody; Chondroitin sulfate proteoglycan NG2 antibody; Cspg4 antibody; Cspg4 chondroitin sulfate proteoglycan 4 antibody; CSPG4_HUMAN antibody; HMW-MAA antibody; HSN tumor-specific antigen antibody; Kiaa4232 antibody; MCSP antibody; MCSPG antibody; MEL-CSPG antibody; Melanoma chondroitin sulfate proteoglycan antibody; Melanoma-associated chondroitin sulfate proteoglycan antibody; MELCSPG antibody; MSK16 antibody; NG2 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q6UVK1

Immunogen

Recombinant Human Chondroitin sulfate proteoglycan 4 protein (1950-2210AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200

Background

Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

CSPG4

Research Areas

Neuroscience; Cancer; Tags & Cell Markers