CSE1L Antibody

Size

100ul

Clone Number

Aliases

CAS antibody; Cellular apoptosis susceptibility protein antibody; Chromosome segregation 1 (yeast homolog) like antibody; Chromosome segregation 1 Like antibody; Chromosome segregation 1 like protein antibody; Chromosome segregation 1-like protein antibody; Chromosome segregation gene CSE1 antibody; CSE 1 antibody; CSE 1 chromosome segregation 1 like antibody; CSE 1 chromosome segregation 1 like protein antibody; CSE 1L antibody; CSE1 antibody; CSE1 chromosome segregation 1 like (yeast) antibody; CSE1 chromosome segregation 1 like antibody; CSE1 chromosome segregation 1 like protein antibody; CSE1L antibody; Exp 2 antibody; Exp2 antibody; Exportin 2 antibody; Exportin-2 antibody; Exportin2 antibody; Importin alpha re exporter antibody; Importin-alpha re-exporter antibody; MGC117283 antibody; MGC130036 antibody; MGC130037 antibody; XPO 2 antibody; XPO2 antibody; XPO2_HUMAN antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

P55060

Immunogen

Recombinant Human Exportin-2 protein (713-971AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, WB, IHC, IF; Recommended dilution: WB:1:1000-1:5000, IHC:1:200-1:500, IF:1:50-1:200

Background

Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

CSE1L

Research Areas

Cancer; Cell biology; Signal transduction