CRTC3 Antibody

Size

100ug

Clone Number

Aliases

CREB regulated transcription coactivator 3 antibody; CREB-regulated transcription coactivator 3 antibody; CRTC 3 antibody; CRTC3 antibody; CRTC3_HUMAN antibody; FLJ21868 antibody; TORC 3 antibody; TORC-3 antibody; TORC3 antibody; Transducer of CREB protein 3 antibody; Transducer of regulated cAMP response element binding protein (CREB) 3 antibody; Transducer of regulated cAMP response element binding protein 3 antibody; Transducer of regulated cAMP response element-binding protein 3 antibody; Transducer of regulated CREB protein 3 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q6UUV7

Immunogen

Recombinant Human CREB-regulated transcription coactivator 3 protein (373-480AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:500-1:1000

Background

Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 \'Ser-133\' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

CRTC3

Research Areas

Epigenetics and Nuclear Signaling; Microbiology