CRMP-2(Phospho Thr514) Polyclonal Antibody

Ab type

Primary antibody

Background

This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance| growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse| and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders| and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

The antiserum was produced against synthesized peptide derived from human DRP-2 around the phosphorylation site of Thr514. AA range:480-529

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

62294

synonyms

Dihydropyrimidinase-related protein 2; DPYSL2; CRMP2; ULIP2; Dihydropyrimidinase-related protein 2; DRP-2; Collapsin response mediator protein 2; CRMP-2; N2A3; Unc-33-like phosphoprotein 2; ULIP-2