Crk II(Phospho Tyr221) Polyclonal Antibody

Ab type

Primary antibody

Background

This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.

Reactivity

Human, Mouse, Rat, Monkey

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

The antiserum was produced against synthesized peptide derived from human CrkII around the phosphorylation site of Tyr221. AA range:187-236

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

33872

synonyms

Adapter molecule crk; CRK; Adapter molecule crk; Proto-oncogene c-Crk; p38