CREB3L1 Antibody, Biotin conjugated

Size

100ug

Clone Number

Aliases

BBF-2 homolog antibody; CAMP responsive element binding protein 3 like 1 antibody; cAMP-responsive element-binding protein 3-like protein 1 antibody; CR3L1_HUMAN antibody; Creb3l1 antibody; Cyclic AMP responsive element binding protein 3 like protein 1 antibody; OASIS antibody; Old astrocyte specifically-induced substance antibody; Processed cyclic AMP-responsive element-binding protein 3-like protein 1 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q96BA8

Immunogen

Recombinant Human Cyclic AMP-responsive element-binding protein 3-like protein 1 protein (396-500AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA

Background

Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in bone formation through the transcription of COL1A1, and possibly COL1A2, and the secretion of bone matrix proteins. Directly binds to the UPR element (UPRE)-like sequence in an osteoblast-specific COL1A1 promoter region and induces its transcription. Does not regulate COL1A1 in other tissues, such as skin (By similarity). Required to protect astrocytes from ER stress-induced cell death. In astrocytes, binds to the cAMP response element (CRE) of the BiP/HSPA5 promoter and participate in its transcriptional activation (By similarity). May play a role in limiting virus spread by inhibiting proliferation of virus-infected cells. Upon infection with diverse DNA and RNA viruses, inhibits cell-cycle progression by binding to promoters and activating transcription of genes encoding cell-cycle inhibitors, such as p21/CDKN1A (PubMed:21767813). Binds the DNA consensus sequence 5\'-GTGXGCXGC-3\' (PubMed:21767813).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Biotin

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

CREB3L1

Research Areas

Epigenetics and Nuclear Signaling; Signal transduction