CRBN Antibody

Size

100ul

Clone Number

Aliases

2610203G15Rik antibody; 2900045O07Rik antibody; AF229032 antibody; AW108261 antibody; Cereblon antibody; Crbn antibody; CRBN_HUMAN antibody; DKFZp781K0715 antibody; MGC27358 antibody; MRT2A antibody; OTTHUMP00000209555 antibody; piL antibody; Protein cereblon antibody; Protein x 0001 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q96SW2

Immunogen

Recombinant Human Protein cereblon protein (1-280AA)

Raised in

Rabbit

Species Reactivity

Human, Mouse

Tested Applications

ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200

Background

Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8. May play a role in memory and learning by regulating the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. Binding of pomalidomide and other thalidomide-related drugs changes the substrate specificity of the human protein, leading to decreased degradation of MEIS2 and other target proteins and increased degradation of MYC, IRF4, IKZF1 and IKZF3.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

CRBN

Research Areas

Neuroscience