Cortactin Polyclonal Antibody

Ab type

Primary antibody

Background

Cortactin, encoded by CTTN gene (formerly EMS1), was originally identified as a substrate of the Src kinase. It is a cytoskeletal protein that interacts with F-actin and Arp2/3 complex and plays an important role in regulation of actin assembly and cytoskeleton dynamics. Overexpression of cortactin increases cell migration, and is thought to contribute to the invasive phennotype of breast cancer and several other tumors. Three isoforms of cortactin exist due to the alternative splicing.

Reactivity

Human;Mouse;Rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

Synthesized peptide derived from the Internal region of human Cortactin.

Storage Stability

-20°C for one year

Concentration

1 mg/ml

MolecularWeight_Da

61636

synonyms

CTTN; EMS1; Src substrate cortactin; Amplaxin; Oncogene EMS1