Cortactin (Acetyl Lys235) Polyclonal Antibody

Ab type

Primary antibody

Background

CTTN is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. Cortactin is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, cortactin is degraded in a caspase-dependent manner. The aberrant regulation of CTTN contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for CTTN.

Reactivity

Human;Mouse;Rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

Synthesized acetyl-peptide derived from the Internal region of human Cortactin around the acetylation site of K235.

Storage Stability

-20°C for one year

Concentration

1 mg/ml

MolecularWeight_Da

61636

synonyms

CTTN; EMS1; Src substrate cortactin; Amplaxin; Oncogene EMS1