COPS4 Antibody

Size

100ul

Clone Number

Aliases

CH4 antibody; COP9 (constitutive photomorphogenic) homolog subunit 4 antibody; COP9 complex homolog subunit 4 antibody; COP9 complex S4 antibody; COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis) antibody; COP9 constitutive photomorphogenic homolog subunit 4 antibody; COP9 signalosome complex subunit 4 antibody; COP9 signalosome subunit 4 antibody; COPS4 antibody; CSN complex subunit 4 antibody; CSN4 antibody; CSN4 SCHPO antibody; CSN4_HUMAN antibody; DCH4 antibody; JAB1 containing signalosome subunit 4 antibody; JAB1-containing signalosome subunit 4 antibody; MGC94896 antibody; SGN4 antibody; Signalosome subunit 4 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9BT78

Immunogen

Recombinant Human COP9 signalosome complex subunit 4 protein (1-310AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, WB, IHC; Recommended dilution: WB:1:200-1:1000, IHC:1:20-1:200

Background

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. Also involved in the deneddylation of non-cullin subunits such as STON2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP and SNAPIN, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

COPS4

Research Areas

Others