COPS3 Antibody

Size

100ul

Clone Number

Aliases

Constitutive photomorphogenic homolog subunit 3 antibody; COP 9 (constitutive photomorphogenic) subunit 3 antibody; COP 9 complex homolog subunit 3 antibody; COP 9 complex S3 antibody; COP 9 complex subunit 3 antibody; COP 9 constitutive photomorphogenic homolog subunit 3 antibody; COP 9 homolog antibody; COP 9 signalosome complex subunit 3 antibody; COP 9 signalosome subunit 3 antibody; COP 9 subunit 3 antibody; COP9 (constitutive photomorphogenic) subunit 3 antibody; COP9 complex homolog subunit 3 antibody; COP9 complex S3 antibody; COP9 complex subunit 3 antibody; COP9 constitutive photomorphogenic homolog subunit 3 antibody; COP9 homolog antibody; COP9 signalosome complex subunit 3 antibody; COP9 signalosome subunit 3 antibody; COP9 subunit 3 antibody; COPS 3 antibody; cops3 antibody; CSN 3 antibody; CSN3 antibody; CSN3_HUMAN antibody; JAB 1 containing signalosome subunit 3 antibody; JAB1 containing signalosome subunit 3 antibody; JAB1-containing signalosome subunit 3 antibody; SGN 3 antibody; SGN3 antibody; Signalosome subunit 3 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9UNS2

Immunogen

Recombinant Human COP9 signalosome complex subunit 3 protein (194-423AA)

Raised in

Rabbit

Species Reactivity

Human, Mouse

Tested Applications

ELISA, WB, IHC, IP; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200, IP:1:200-1:2000

Background

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

COPS3

Research Areas

Neuroscience; Cell biology