Collagen XVIII alpha 1(Cleaved-His1572) Rabbit Polyclonal Antibody

Ab type

Primary antibody

Background

This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins| extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. A long isoform of the protein has an N-terminal domain that is homologous to the extracellular part of frizzled receptors. Proteolytic processing at several endogenous cleavage sites in the C-terminal domain results in production of endostatin| a potent antiangiogenic protein that is able to inhibit angiogenesis and tumor growth. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities| so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternative splicing results in multiple transcript variants.

Reactivity

Human, Mouse

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

Synthesized peptide derived from human Collagen XVIII α1 (Cleaved-His1572)

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

192940

synonyms

Collagen XVIII α1 ;Cleaved-His1572; Collagen alpha-1;XVIII chain [Cleaved into: Endostatin;