Cofilin Polyclonal Antibody

Ab type

Primary antibody

Background

Cofilin 1 encoded by CFL1 can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.

Reactivity

Human;Mouse;Rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

The antiserum was produced against synthesized peptide derived from human Cofilin. AA range:1-50

Storage Stability

-20°C for one year

Concentration

1 mg/ml

MolecularWeight_Da

18371

synonyms

CFL1; CFL; Cofilin-1; 18 kDa phosphoprotein; p18; Cofilin; non-muscle isoform