CNOT8 Antibody

Size

100ul

Clone Number

Aliases

CAF 1 antibody; CAF 2 antibody; CAF1 antibody; CAF1 like protein antibody; CAF1-like protein antibody; CAF2 antibody; CALIF antibody; CALIFp antibody; CCR4 associated factor 8 antibody; CCR4 NOT transcription complex subunit 8 antibody; CCR4-associated factor 8 antibody; CCR4-NOT transcription complex subunit 8 antibody; CNOT 8 antibody; Cnot8 antibody; CNOT8_HUMAN antibody; hCAF1 antibody; PGK promoter directed over production antibody; POP 2 antibody; POP2 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9UFF9

Immunogen

Recombinant Human CCR4-NOT transcription complex subunit 8 protein (1-292AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

Has 3\\\'-5\\\' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

CNOT8

Research Areas

Epigenetics and Nuclear Signaling