CNOT3 Antibody

Size

100ug

Clone Number

Aliases

CCR4 associated factor 3 antibody; CCR4-associated factor 3 antibody; CCR4-NOT transcription complex subunit 3 antibody; CNOT3 antibody; CNOT3_HUMAN antibody; KIAA0691 antibody; LENG2 antibody; Leukocyte receptor cluster member 2 antibody; negative regulator of transcription 3, S. cerevisiae, homolog of antibody; NOT3 (negative regulator of transcription 3, yeast) homolog antibody; NOT3 antibody; NOT3H antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

O75175

Immunogen

Recombinant Human CCR4-NOT transcription complex subunit 3 protein (257-395AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:20-1:200

Background

Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of emryonic stem (ES) cell identity.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

CNOT3

Research Areas

Epigenetics and Nuclear Signaling; Cardiovascular