CNGA3 Antibody

Size

100ul

Clone Number

Aliases

ACHM2 antibody; CCNC1 antibody; CCNCa antibody; CCNCalpha antibody; CNCG3 antibody; CNG 3 antibody; CNG channel alpha 3 antibody; CNG channel alpha-3 antibody; CNG-3 antibody; CNG3 antibody; CNGA3 antibody; Cnga3 cyclic nucleotide gated channel alpha 3 antibody; CNGA3_HUMAN antibody; Cone photoreceptor cGMP gated channel antibody; Cone photoreceptor cGMP gated channel alpha subunit antibody; Cone photoreceptor cGMP gated channel subunit alpha antibody; Cone photoreceptor cGMP-gated channel subunit alpha antibody; Cyclic nucleotide gated cation channel alpha 3 antibody; Cyclic nucleotide gated channel alpha 3 antibody; Cyclic nucleotide gated channel olfactory 3 antibody; Cyclic nucleotide gated channel rod photoreceptor subunit alpha antibody; Cyclic nucleotide-gated cation channel alpha-3 antibody; Cyclic nucleotide-gated channel alpha-3 antibody; OTTHUMP00000161120 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q16281

Immunogen

Recombinant Human Cyclic nucleotide-gated cation channel alpha-3 protein (1-165AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGB3 (By similarity). Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

CNGA3

Research Areas

Neuroscience