Cleaved-Thrombin APII (R327) Polyclonal Antibody

Ab type

Primary antibody

Background

Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Peptides derived from the C-terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in F2 lead to various forms of thrombosis and dysprothrombinemia. Alternative splicing results in multiple transcript variants.

Reactivity

Human

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

The antiserum was produced against synthesized peptide derived from human THRB. AA range:278-327

Storage Stability

-20°C for one year

Concentration

1 mg/ml

MolecularWeight_Da

70037

synonyms

F2; Prothrombin; Coagulation factor II