Cleaved-Plasma Kallikrein HC (R390) Polyclonal Antibody

Ab type

Primary antibody

Background

KLKB1 encodes a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. The encoded preproprotein present in plasma as a non-covalent complex with high molecular weight kininogen undergoes proteolytic processing mediated by activated coagulation factor XII to generate a disulfide-linked, heterodimeric serine protease comprised of heavy and light chains. Certain mutations in KLKB1 cause prekallikrein deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms.

Reactivity

Human

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

The antiserum was produced against synthesized peptide derived from human KLKB1. AA range:341-390

Storage Stability

-20°C for one year

Concentration

1 mg/ml

MolecularWeight_Da

71370

synonyms

KLKB1; KLK3; Plasma kallikrein; Fletcher factor; Kininogenin; Plasma prekallikrein