Cleaved-Integrin  Alpha6 LC (E942) Polyclonal Antibody

Ab type

Primary antibody

Background

ITGA6 encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit. This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. The alpha 6 beta 4 integrin may promote tumorigenesis, while the alpha 6 beta 1 integrin may negatively regulate erbB2/HER2 signaling. Alternative splicing results in multiple transcript variants.

Reactivity

Human

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

The antiserum was produced against synthesized peptide derived from human ITGA6. AA range:923-972

Storage Stability

-20°C for one year

Concentration

1 mg/ml

MolecularWeight_Da

126619

synonyms

ITGA6; Integrin alpha-6; CD49 antigen-like family member F; VLA-6; CD antigen CD49f