Cleaved-Cathepsin L1 HC (T288) Polyclonal Antibody

Ab type

Primary antibody

Background

The protein encoded by CTSL is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein (cathepsin L) has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. cathepsin L, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Multiple alternatively spliced transcript variants have been found for CTSL.

Reactivity

Human

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

The antiserum was produced against synthesized peptide derived from human CATL1. AA range:239-288

Storage Stability

-20°C for one year

Concentration

1 mg/ml

MolecularWeight_Da

37564

synonyms

CTSL1; CTSL; Cathepsin L1; Major excreted protein; MEP