Cleaved-Caspase-6 p11 (A194) Polyclonal Antibody

Ab type

Primary antibody

Background

CASP6 (caspase 6) encodes a member of the cysteine-aspartic acid protease (caspase) family of enzymes. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic acid residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of CASP6 results in multiple transcript variants that encode different isoforms.

Reactivity

Human;Mouse;Rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

Synthesized peptide derived from Cleaved-Caspase-6 p11 (A194) . at AA range: 150-230

Storage Stability

-20°C for one year

Concentration

1 mg/ml

MolecularWeight_Da

33310

synonyms

caspase 6, apoptosis-related cysteine peptidase