Cleaved-Caspase-4 p20 (Q81) Polyclonal Antibody

Ab type

Primary antibody

Background

CASP4 encodes caspase 4 that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, CASP4 induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms.

Reactivity

Human

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

The antiserum was produced against synthesized peptide derived from human Caspase 4. AA range:62-111

Storage Stability

-20°C for one year

Concentration

1 mg/ml

MolecularWeight_Da

43262

synonyms

CASP4; ICH2; Caspase-4; CASP-4; ICE(rel)-II; Protease ICH-2; Protease TX