CLDN1 Antibody

Size

100ug

Clone Number

Aliases

Claudin-1 antibody; Claudin1 antibody; CLD 1 antibody; CLD1 antibody; CLD1_HUMAN antibody; CLDN 1 antibody; Cldn1 antibody; ILVASC antibody; SEMP 1 antibody; SEMP1 antibody; Senescence associated epithelial membrane protein 1 antibody; Senescence associated epithelial membrane protein antibody; Senescence-associated epithelial membrane protein antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

O95832

Immunogen

Recombinant Human Claudin-1 protein (24-161AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

Background

Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions (PubMed:23407391).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

CLDN1

Research Areas

Signal transduction