CISH Antibody

Size

100ul

Clone Number

Aliases

BACTS2 antibody; cis 1 antibody; CIS antibody; CIS-1 antibody; CIS1 antibody; Cish antibody; CISH_HUMAN antibody; Cytokine inducible inhibitor of signaling type 1B antibody; Cytokine inducible SH2 containing protein antibody; Cytokine-inducible SH2-containing protein antibody; G18 antibody; Protein G18 antibody; SOCS antibody; Suppressor of cytokine signaling antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9NSE2

Immunogen

Recombinant Human Cytokine-inducible SH2-containing protein (1-257AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

CISH

Research Areas

Epigenetics and Nuclear Signaling; Signal transduction