CIDEA Antibody, HRP conjugated

Size

100ug

Clone Number

Aliases

CIDEACell death activator CIDE-A antibody; Cell death-inducing DFFA-like effector A antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

O60543

Immunogen

Recombinant Human Cell death activator CIDE-A protein (1-51AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA

Background

Acts as a CEBPB coactivator in mammary epithelial cells to control the expression of a subset of CEBPB downstream target genes, including ID2, IGF1, PRLR, SOCS1, SOCS3, XDH, but not casein. By interacting with CEBPB, strengthens the association of CEBPB with the XDH promoter, increases histone acetylation and dissociates HDAC1 from the promoter (By similarity). Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair and occurs at a lower rate than that promoted by CIDEC. When overexpressed, induces apoptosis. The physiological significance of its role in apoptosis is unclear.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

HRP

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

CIDEA

Research Areas

Epigenetics and Nuclear Signaling; Cancer; Cardiovascular; Cell biology; Metabolism