CHRNA9 Antibody

Size

100ul

Clone Number

Aliases

CHRNA9 antibody; NACHRA9Neuronal acetylcholine receptor subunit alpha-9 antibody; Nicotinic acetylcholine receptor subunit alpha-9 antibody; NACHR alpha-9 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9UGM1

Immunogen

Recombinant Human Neuronal acetylcholine receptor subunit alpha-9 protein (26-240AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding induces a conformation change that leads to the opening of an ion-conducting channel across the plasma membrane (PubMed:11752216, PubMed:25282151). The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane (PubMed:11752216, PubMed:25282151). In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. May also regulate keratinocyte adhesion (PubMed:11021840).

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

CHRNA9

Research Areas

Neuroscience