Choactase Polyclonal Antibody

Ab type

Primary antibody

Background

CHAT encodes an enzyme which catalyzes the biosynthesis of the neurotransmitter acetylcholine. CHAT product (choline O-acetyltransferase) is a characteristic feature of cholinergic neurons, and changes in these neurons may explain some of the symptoms of Alzheimer's disease. Polymorphisms in CHAT have been associated with Alzheimer's disease and mild cognitive impairment. Mutations in CHAT are associated with congenital myasthenic syndrome associated with episodic apnea. Multiple transcript variants encoding different isoforms have been found for CHAT, and some of these variants have been shown to encode more than one isoform.

Reactivity

Human;Mouse;Rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

The antiserum was produced against synthesized peptide derived from human Choactase. AA range:334-383

Storage Stability

-20°C for one year

Concentration

1 mg/ml

MolecularWeight_Da

82568/74361/70394

synonyms

CHAT; Choline O-acetyltransferase; CHOACTase; ChAT; Choline acetylase