Chk2(Phospho-Ser19) Rabbit Polyclonal Antibody

Ab type

Primary antibody

Background

In response to DNA damage and replication blocks| cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated| the encoded protein is known to inhibit CDC25C phosphatase| preventing entry into mitosis| and has been shown to stabilize the tumor suppressor protein p53| leading to cell cycle arrest in G1. In addition| this protein interacts with and phosphorylates BRCA1| allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome| a highly penetrant familial cancer phenotype usually associated with inherited mutati

Reactivity

Human, Rat, Mouse

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

Synthesized phosho peptide around human Chk2 (Ser19)

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

synonyms

Chk2 ;Ser19; Serine/threonine-protein kinase Chk2; EC 2.7.11.1; CHK2 checkpoint homolog; Cds1 homolog; Hucds1; hCds1; Checkpoint kinase 2