CHGA Monoclonal Antibody

Size

100ug

Clone Number

1A11C11

Aliases

Chromogranin-A,CgA,Pituitary secretory protein I,SP-I,Vasostatin II,CHGA

Immunogen Species

Human

UniProt ID

P10645

Immunogen

Recombinant CHGA Protein

Raised in

Mouse

Species Reactivity

Human

Tested Applications

ELISA,WB,IHC;Recommended dilution:WB:1:500-1:5000,IHC:1:50-1:500

Background

Chromogranin A is a member of the granin family of neuroendocrine secretory proteins. It is located in secretory vesicles of neurons and endocrine cells. Chromogranin A is the precursor to several functional peptides including vasostatin, pancreastatin, catestatin and parastatin. These peptides negatively modulate the neuroendocrine function of the releasing cell (autocrine) or nearby cells (paracrine). CgA is one of the most used tumor markers in NET's (neuroendocrine tumors) , and elevated CgA concentrations have been demonstrated in serum or plasma of patients with different types of these tumors. However, CgA is not a tumor-specific antigen for NETs, and an abnormal concentration has been described in some non-malignant diseases such as renal failure, heart failure, proton pump inhibition, gastritis, hypertension, or patients with liver diseases.

Clonality

Monoclonal

Isotype

IgG1

Purification Method

>95%,Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

CHGA

Research Areas

Neuroscience?Cancer;Tags & Cell Markers;Signal transduction