CHD1 Antibody

Size

100ul

Clone Number

Aliases

ATP dependent helicase CHD 1 antibody; ATP-dependent helicase CHD1 antibody; CHD 1 antibody; CHD-1 antibody; Chd1 antibody; CHD1_HUMAN antibody; Chromodomain helicase DNA binding protein 1 antibody; Chromodomain-helicase-DNA-binding protein 1 antibody; DKFZp686E2337 antibody; OTTHUMP00000222625 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

O14646

Immunogen

Recombinant Human Chromodomain-helicase-DNA-binding protein 1 protein (1501-1710AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC, ChIP; Recommended dilution: IHC:1:20-1:200

Background

ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3. Required for maintaining open chromatin and pluripotency in embryonic stem cells.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

CHD1

Research Areas

Epigenetics and Nuclear Signaling