CHAC1 Antibody

Size

100ug

Clone Number

Aliases

Blocks Notch protein antibody; Botch antibody; Cation transport regulator like protein 1 antibody; Cation transport regulator-like protein 1 antibody; ChaC antibody; ChaC cation transport regulator homolog 1 antibody; ChaC cation transport regulator like 1 antibody; chac1 antibody; CHAC1_HUMAN antibody; Gamma GCT acting on glutathione homolog 1 antibody; Gamma-GCG 1 antibody; Glutathione-specific gamma-glutamylcyclotransferase 1 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9BUX1

Immunogen

Recombinant Human Glutathione-specific gamma-glutamylcyclotransferase 1 protein (43-264AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:500

Background

Catalyzes the cleavage glutathione into 5-oxoproline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. Glutathione depletion is an important factor for apoptosis initiation and execution (PubMed:23070364). Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade (PubMed:19109178). Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos (PubMed:22445366).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

CHAC1

Research Areas

Cell biology