CFLAR Antibody

Size

100ug

Clone Number

Aliases

c FLIP antibody; c FLIPL antibody; c FLIPR antibody; c FLIPS antibody; c-FLIP antibody; c-FLIPL antibody; c-FLIPR antibody; c-FLIPS antibody; CASH antibody; CASP8 and FADD like apoptosis regulator antibody; CASP8 and FADD-like apoptosis regulator subunit p12 antibody; CASP8AP1 antibody; Caspase homolog antibody; Caspase like apoptosis regulatory protein antibody; Caspase related inducer of apoptosis antibody; Caspase-eight-related protein antibody; Caspase-like apoptosis regulatory protein antibody; Casper antibody; cellular flice inhibitory protein antibody; Cellular FLICE-like inhibitory protein antibody; CFLA antibody; Cflar antibody; CFLAR_HUMAN antibody; CLARP antibody; FADD like anti apoptotic molecule antibody; FADD-like antiapoptotic molecule 1 antibody; FLAME antibody; FLAME-1 antibody; FLAME1 antibody; FLIP antibody; I FLICE antibody; I-FLICE antibody; Inhibitor of FLICE antibody; MACH-related inducer of toxicity antibody; MRIT antibody; OTTHUMP00000163715 antibody; OTTHUMP00000206475 antibody; OTTHUMP00000206476 antibody; OTTHUMP00000206478 antibody; OTTHUMP00000206479 antibody; OTTHUMP00000206480 antibody; OTTHUMP00000206482 antibody; OTTHUMP00000207360 antibody; Usurpin antibody; Usurpin beta antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

O15519

Immunogen

Recombinant Human CASP8 and FADD-like apoptosis regulator protein (1-250AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:5000, IHC:1:200-1:500, IF:1:20-1:200

Background

Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

CFLAR

Research Areas

Cancer; Cell biology; Metabolism; Signal transduction