Centriolin Polyclonal Antibody

Ab type

Primary antibody

Background

Cytokinesis occurs during the late stages of mitosis and describes the process by which the cytoplasm of one cell is divided to create two subsequent daughter cells. Centriolin, also known as CEP110, is a coiled-coil centrosomal protein that is required for centrosome maturation and correct centrosome function. During abscission, the last step in cytokinesis, Centriolin both coordinates and grounds vesicle-fusion and vesicle-exocyst complexes to the midbody of the daughter cells. Acting as an anchor for the protein complexes needed to complete separation of the two cells, Centriolin initiates and controls vesicle-mediated cell cleavage. Through its ability to signal initiation of the last step of vertebrate cytokinesis, Centriolin regulates cell proliferation and contributes to proper entry into the S phase of mitosis.

Reactivity

Human

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

The antiserum was produced against synthesized peptide derived from human CEP110. AA range:850-900

Storage Stability

-20°C for one year

Concentration

1 mg/ml

MolecularWeight_Da

113424

synonyms

CCP110; CEP110; CP110; KIAA0419; Centriolar coiled-coil protein of 110 kDa; Centrosomal protein of 110 kDa; CP110; Cep110