CELF4 Antibody

Size

100ug

Clone Number

Aliases

CELF4 antibody; BRUNOL4 antibody; CUGBP Elav-like family member 4 antibody; CELF-4 antibody; Bruno-like protein 4 antibody; CUG-BP- and ETR-3-like factor 4 antibody; RNA-binding protein BRUNOL-4 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9BZC1

Immunogen

Recombinant Human CUGBP Elav-like family member 4 protein (120-236AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:200-1:500

Background

RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Promotes exclusion of both the smooth muscle (SM) and non-muscle (NM) exons in actinin pre-mRNAs. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

CELF4

Research Areas

Epigenetics and Nuclear Signaling