CEL3B Rabbit Polyclonal Antibody

Ab type

Primary antibody

Background

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1| 2| 2A| 2B| 3A| and 3B. Unlike other elastases| elastase 3B has little elastolytic activity. Like most of the human elastases| elastase 3B is secreted from the pancreas as a zymogen and| like other serine proteases such as trypsin| chymotrypsin and kallikrein| it has a digestive function in the intestine. Elastase 3B preferentially cleaves proteins after alanine residues. Elastase 3B may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1| and excretion of this protein in fecal material is frequently used as a measure of pancreatic function in clinical assays.

Reactivity

Human, Mouse

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

Synthesized peptide derived from human CEL3B

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

29700

synonyms

CEL3B